Estimation of statistical power and false discovery rate of QTL mapping methods through computer simulation
نویسندگان
چکیده
منابع مشابه
the effect of vocabulary instruction through semantic mapping on learning and recall of efl learners
چکیده ندارد.
15 صفحه اولImproving false discovery rate estimation
MOTIVATION Recent attempts to account for multiple testing in the analysis of microarray data have focused on controlling the false discovery rate (FDR). However, rigorous control of the FDR at a preselected level is often impractical. Consequently, it has been suggested to use the q-value as an estimate of the proportion of false discoveries among a set of significant findings. However, such a...
متن کاملRobust estimation of the false discovery rate
MOTIVATION Presently available methods that use p-values to estimate or control the false discovery rate (FDR) implicitly assume that p-values are continuously distributed and based on two-sided tests. Therefore, it is difficult to reliably estimate the FDR when p-values are discrete or based on one-sided tests. RESULTS A simple and robust method to estimate the FDR is proposed. The proposed ...
متن کاملStatistical Methods for Mapping Multiple QTL
Since Lander and Botstein proposed the interval mapping method for QTL mapping data analysis in 1989, tremendous progress has been made in the last many years to advance new and powerful statistical methods for QTL analysis. Recent research progress has been focused on statistical methods and issues for mapping multiple QTL together. In this article, we review this progress. We focus the discus...
متن کاملFalse Discovery Rate Estimation in Proteomics.
With the advancement in proteomics separation techniques and improvements in mass analyzers, the data generated in a mass-spectrometry based proteomics experiment is rising exponentially. Such voluminous datasets necessitate automated computational tools for high-throughput data analysis and appropriate statistical control. The data is searched using one or more of the several popular database ...
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ژورنال
عنوان ژورنال: Chinese Science Bulletin
سال: 2012
ISSN: 1001-6538,1861-9541
DOI: 10.1007/s11434-012-5239-3